GENERATION OF TUMOR-SPECIFIC CYTOTOXIC T CELLS FROM BLOOD VIA IN VITRO EXPANSION USING AUTOLOGOUS DENDRITIC CELLS PULSED WITH NEOANTIGEN-COUPLED MICROBEADS

For the past decade, adoptive cell therapy including tumor-infiltrating lymphocytes, genetically modified cytotoxic lymphocytes expressing a chimeric antigen receptor, or a novel T-cell receptor has revolutionized the treatment of many cancers.Progress within exome sequencing and neoantigen prediction technologies provides opportunities for further

Abstract Background Compulsivity, the closely linked trait impulsivity and addictive behaviour are associated with several neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive compulsive disorder (OCD).All three disorders show impaired fronto-striatal functioning, whi

Polymeric solid foams have several beneficial properties such as their light weight, thermal insulation or shock absorbance, royal nomadic 5413 rug but it is still challenging to efficiently control the foam architecture.Here, the authors optimize the frontal polymerization of dicyclopentadiene with allyl-functionalized cellulose nanocrystals to ra

Abstract As global temperatures rise, heat-related chronic health disorders are predicted to become more prevalent.We tested whether a single exposure to acute heat illness, using a preclinical mouse model of exertional heat stroke (EHS), can induce late-emerging health disorders that progress into chronic disease.Following EHS, mice were followed

Global warming could increase climatic instability and large wildfire activity in circumboreal regions, potentially impairing both ecosystem functioning and human health.However, links between large wildfire events and climatic and/or meteorological conditions are still poorly understood, partly because few studies have covered a wide range of past